Analysis of the Correlation Between Pregnancy Complications and Placental Histopathology: A Study of Samples from Shahid Sadoughi Hospital, Yazd, Iran (2013-2022)
Alireza Torki
ABSTRACT
Aims: This study aimed to investigate the correlation between pregnancy complications and placental histopathology in samples collected at Shahid Sadoughi Hospital in Yazd from 2013 to 2022.
Method: A census sampling approach was utilized to examine all placental samples submitted to the pathology department at Shahid Sadoughi Hospital between 2012 and 2014. Following approval from the Research Council of the Faculty of Medicine at Shahid Sadoughi University of Medical Sciences in Yazd and clearance from the ethics committee, the study commenced. Stakeholders were briefed on the study objectives, methodology, and data confidentiality. Patient records were scrutinized based on predefined criteria, and relevant information was extracted.
Results: The retrospective analysis included 210 subjects with an average age of 28.78±5.51 years. The average gestational age in the sampled cases was 32.98±4.09 weeks. The highest incidence of pregnancy-related pathologies was attributed to IUGR at 20.0% and IUFD at 18.1%. The predominant placental histopathological findings were categorized as no significant abnormalities (26.2%) and multifocal ischemic changes (21.0%).
Conclusion: The study findings establish a significant association between pregnancy complications like IUGR and IUFD and specific placental histopathological patterns. Notably, a substantial proportion of cases exhibited diverse placental histopathologies, particularly those with unremarkable findings and multiple ischemic changes. These results underscore the importance of diligent placental histopathological assessments in the investigation of pregnancy complications, aiding in enhanced clinical decision-making. The study recommends comprehensive placental histopathological evaluations in suspected high-risk pregnancies to improve clinical management strategies.
