Haemotoxicological Studies of Ethanolic Extract of Pericarp of Dried Mature Fruits of Emblica Officinalis Gaertn. In Swiss Albino Rats
Kamrun Nahar*, Md. Shanawes Hossen Rasel, Mohammad Abbas Gani, Fatema Tuj Johora Faria, Anika Tabassum Sumaya and Md. Sahabuddin Kabir Chowdhury
ABSTRACT
Embilica officinalis has been traditionally used for many purposes through decades. This study aims to evaluate the safety of the ethanolic fruit extract of the dried mature Pericarp of Embilica officinalis. The extract was administered for 28 days at 50 mg/kg and 400 mg/kg in Swiss albino rats. After 28 days of the administration, the rats were sacrificed to evaluate the haematological profile. The result shows that, in case of WBC parameter, the extract has a highly significant effect on total WBC (↑ 24.01% increase in 50mg/kg and ↓66.4% decrease in 400mg/kg), Neutrophil (↓ 24.16% decrease in 50 mg/kg and 34.61% in decrease in 400 mg/kg) and Lymphocyte (15.16% increase in 500 mg/kg); in case of RBC, there was significant effect on Hematocrit (8.7% decrease in 50 mg/kg); in case of platelet, there is significant effect on the total platelet ( 10.53% decrease in 400 mg/kg) and Plateletcrit (11.37 % decrease in 400 mg/kg). From the data, it can be safely concluded that this medication has a direct effect on haematopoiesis or is an immune booster, but in case of prolonged use at a higher dose, one should look for thrombocytopenia or any problem associated with it.
