LIGHT/TNFSF14 in Tissue Homeostasis and Disease
Giacomina Brunetti
LIGHT is a proinflammatory cytokine expressed by immune cells. Its action is linked to the binding with the receptor HVEM, LTβR and DcR3 (The last expressed only in human cells). It has a wide range of functions and different organs and tissues can be affected according to the levels of inflammation. In this review the involvement of LIGHT in homeostasis and disease in human and animal models has been evaluated in intestine, adipose tissue, liver, bone and heart, highlighting its role as potential therapeutic target in pathologies characterized by the dysregulated LIGHT levels. All these studies are important because monoclonal antibodies against LIGHT have been realized, leading to a precise target, the studies evaluating the efficacy will be published soon and will be usefull in precision medicine.
