Prevalence And Predictors of Hyperuricemia Among Adults with Chronic Diseases in Ethiopia: A Systematic Review and Meta-Analysis 2025
Amanuel Aklilu Alemu*, Sumeya Hussen Idris*, Elias Getahun Bayu, Tsion Kebede Tegene, Gebremedhin Hailay Tsadik*, Elias Gashaw Endegnanew, Biruk Tadesse Officer, Haymanot Bekele Urga, Misrak Handamo, Tsion Tesfaye Degefu*, Sherefedin Kedir Rashed, Temesgen Teklu Alemayehu, Meron Teklay Girmay and Tewodros Kassahun Tarekegn
ABSTRACT
Introduction: Hyperuricemia has been linked to gout, cardiovascular diseases, resistant hypertension, insulin resistance, chronic kidney disease, and progression of type 2 diabetes mellitus. Current population wide estimates of hyperuricemia are limited; data from related conditions such as gout and other chronic disease indicate a rising trend in both prevalence and disability. So, this study is aimed to estimate pooled prevalence and predictors of hyperuricemia among adult with chronic disease in Ethiopia
Methods: PubMed, Scopus, PsycINFO, and goggle scholar databases were used for this analysis. We assessed methodological quality using the Newcastle-Ottawa Scale. An inverse variance-weighted random-effects model meta-analysis was performed to estimate the pooled prevalence and odds ratio (OR) of determinants with a 95% confidence interval (CI). The I2 test statistic was used to check between study heterogeneity, and the Egger's regression statistical test was used to check publication bias. A p-value of less than 0.05 used to declare statistical significance.
Results: All ten articles had good methodological quality and included 2917 participants. The prevalence of hyperuricemia ranged from 22-66.1%. The highest prevalence 47.0%; (95% CI: 27.9-, 66.2), was seen in Amhara region and the lowest 31.5%; 95% CI: 12.6-50.5), seen in Oromia region: whereas the pooled prevalence hyperuricemia among adults with chronic disease with a random-effects model was 37.5% (95% CI: 30.6). From extracted variables BMI is significantly associated with hyperuricemia.
Conclusion: Despite of hyperuricemia can be easily diagnosed and largely preventable this study showed that hyperuricemia is highly prevalent among adults with chronic diseases, with more than one-third of patients affected. Also, above-normal BMI showed a significantly associated with hyperuricemia. So early identification and targeted prevention strategies needed to reduce the burden of hyperuricemia and
complications on these risky groups.
